There is concern over the number of allergic reactions, including anaphylaxis, with the use of ambroxol (to which bromhexine is metabolised). Bromhexine is an expectorant used in the treatment of respiratory disorders associated with from infant on. Bromhexine is well established and tolerated. Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin. Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. Recently, a hypothesis.

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Many state-of-the-art clinical studies [7] have demonstrated the efficacy of ambroxol in relieving pain in acute sore throat, with a rapid onset of action, with its effect lasting at least three hours. Cough and cold preparations R Codeine-containing products used for bfomhexina and cold symptoms are restricted to adults and children 12 years of age and over.

Retrieved from ” https: For this reason it is often added to cough syrups. Information for healthcare professionals Bromhexine-containing medicines used for cough and cold symptoms are restricted to adults ambroxo, children six years of age and over. Ambroxol is a drug that breaks up phlegmused in the treatment of respiratory diseases associated with viscid or excessive mucus.

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. Ambroxol formulations for injection are also used in premature and newborn babies to treat respiratory distress syndrome, a condition in which the baby’s lungs are too immature for the baby to breathe properly. Trans-Tasman Early Warning System – Alert Communication Changes to the use of v or codeine-containing cough and cold medicines in children 29 April 5 Information for consumers and caregivers Information for healthcare professionals Review Summary What actions are Medsafe taking?


Ambroxol and bromhexine expectorants: There is concern regarding morphine-induced respiratory depression due to differences in codeine metabolism, particularly in young patients.

Medsafe: New Zealand Medicines and Medical Devices Safety Authority

The main goal of treatment is thus to reduce pain. Discuss the benefits and risk of harms of bromhexine or codeine treatment before commencing ambtoxol. July Learn how and when to remove this template message. In other projects Wikimedia Commons.

In addition, bromhexine has antioxidant properties.

Ambroxol and bromhexine expectorants: safety information to be updated | European Medicines Agency

As a result, SCARs are now to be listed as side effects in the product information for these medicines, and patients are to stop treatment immediately if symptoms of SCARs occur. However, caution is suggested for patients with gastric ulceration, and usage during the first trimester of pregnancy bromhdxina not recommended. Human regulatory Overview Research and development Marketing authorisation Post-authorisation Herbal products. Leave this field blank.

It was also recently shown that ambroxol triggers exocytosis of lysosomes by releasing calcium from acidic cellular calcium stores. Ambroxol also provides pain relief in acute sore throat. It is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport”.


The majority of these medicines are available over the counter, whereas some are prescription-only medicines, depending on the condition to be treated and how the treatment is given. We sell medications at their cost price only without any additional fees! The medicines are widely available in the EU for use as expectorants to help clear mucus from the airways.


This page was last edited on 18 Septemberat Because of this it may be a useful therapeutic agent for both Gaucher disease and Parkinson’s disease. The posology varies with the age and weight, but there are products for all age groups from infant on.

This much-coveted process for segrate while operations against internet research, injectables, amvroxol your product! The CMDh is a regulatory body representing EU Member States, and is responsible for ensuring harmonised safety standards for medicines authorised via national procedures across the EU. The Cough and Cold Review Group recommended that children with cough and colds should be allowed to rest, be made comfortable and be given plenty of fluids.

How to report adverse events Further information Bromhexine is a mucolytic, a medicine used to break up excessive or thick phlegm associated with a chesty cough.

Medicines Adverse Reactions Committee minutes of the th meeting [www.