Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.
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D-penicillamine induced elastic fiber alteration may not always manifest clinically as EPS. Biopsy specimen demonstrating transepidermal elimination of altered elastic fibers. In the latter case, the treatment has not been undertaken [ 6 ]. There are also conflicting reports about the positive therapeutic effect of laser therapy, including CO 2 laser, Er: Four types of elastosis perforans serpiginosa EPS have been described in literature: This article has been serpginosa by.
Elastosis Perforans Serpiginosa
A potassium hydroxide preparation obtained from the skin lesion was negative for fungal elements. The mechanism of action of tazarotene in treating EPS is unknown. Many elastic fibers were noted to be pushing through epidermal channels Figure 1a finding that was consistent with the clinical diagnosis of elastosis perforans serpiginosa EPS. The last subtype, idiopathic one, may be associated with genetic basis of the autosomal dominant type of inheritance.
The middle of each lesion is umbilicated from which the material containing damaged elastic fibers is extruded [ 12 ]. DermNet NZ does not provide an online consultation service.
Am J Clin Dermatol. Tazarotene is an effective therapy for elastosis perforans serpiginosa. Adjacent inflammation with dermal necrosis, both within and surrounding the epithelia, was evident.
This study was presented as a poster at the annual meeting of the American Academy of Dermatology, San Francisco, Calif, March Views Read Edit View history. The patient stated that the skin lesions had developed after a skin injury.
However, the irritation subsided after a few weeks of therapy. A year-old man presented to Gangnam Severance Hospital with a 2-year history of skin elashosis on his neck, which were refractory to topical antifungal or steroid treatment. Verhoeff-van Gieson staining showed a markedly increased number of altered elastic fibers forming dense clumps in the upper dermis Fig.
Elastosis perforans serpiginosa EPS is a rare disorder classified as a primary perforating dermatosis. Find articles by Si-Hyung Lee. Penicillamine-induced pseudoxanthoma elasticum with elastosis perforans serpiginosa: Treatment with topical tretinoin including topical 0. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more.
Elastosis perforans serpiginosa: a review of the literature and our own experience
Sign in to customize your interests Sign in to your personal account. Tazarotene is serpiinosa first receptor-selective topical retinoid approved for the treatment of plaque psoriasis. The result is a papular eruption that is usually arranged serpiginously, annularly, or arcuately. These lesions were associated with a 6-cm-long scar on the posterolateral aspect of the left side of the neck.
Elastosis perforans serpiginosa | DermNet NZ
Click on image for details. Over time, the skin lesions had spread peripherally with some central clearing. A biopsy was performed approximately 1 year before her presentation to our institution. Many of elaatosis elastic fibers appeared clumped and thickened. Published online Oct Sign in to save your search Sign in to your personal account. This condition is inherited in an autosomal dominant manner.
Elastosis Perforans Serpiginosa
Purchase access Subscribe now. Elatsosis amount and thickness of the elastic fibers in the papillary dermis had increased markedly. This article has been cited by other articles in PMC. Get free access to newly published articles.
A year-old woman was referred to our institution for evaluation of a prutitic “nonhealing scar” that had been present on the posterolateral aspect of the left side of her neck for 1 year. A marker of long-term administration of penicillamine.
Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of Wilson’s disease with penicillamine.
The papillary dermis and superficial reticular dermis were infiltrated by numerous inflammatory cells, including lymphocytes and histiocytes Fig.
It appears to be more common in males than females ratio 4: In addition, the patient was suffering from hypothyroidism, tetralogy of Fallot and bilateral congenital dislocation of the hip joints.